反应详情

9.25 g (43.2 mmol) of 5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienylmethyl methanesulphonate are dissolved in 100 mL of 2-butanone, and 9.07 g (43.2 mmol) of dimethyl 4-hydroxyphthalate (prepared in Example 1(b)), 6 g of potassium carbonate (43.2 mmol) and 20 mg of sodium iodide are added. The mixture is refluxed for 12 hours, cooled and filtered. The filtrate is concentrated under reduced pressure and then purified by chromatography on a column of silica. A yellow oil is obtained (m=12.70 g; Y=73%).

1. temperatureThe mixture is refluxed for 12 hours
2. temperaturecooled
3. filtrationfiltered
4. concentrationThe filtrate is concentrated under reduced pressure
5. custompurified by chromatography on a column of silica
6. customA yellow oil is obtained (m=12.70 g; Y=73%)