Acetic Anhydride → HCID 22036362, compound

Participants

Reaction Steps

Acetic anhydride (0.24 g, 2.4 mmol) was added to a stirred mixture of the title compound from Step 1 above (0 30 g, 1.66 mmol) and Et3N (0.70 g, 6.9 mmol) in CH2Cl2 (30 mL) The reaction was stirred at room temperature for 15 h More acetic anhydride (0.10 g, 1.0 mmol) was added and the mixture was stirred for a further 5 h at room temperature. The mixture was concentrated and the residue purified by chromatography on silica gel using EtOAc/isohexane (1.3 to 2:3) as eluent to give 170 mg (46%) of the title product as an oil.

Provenance & Evidence