Potassium Carbonate → 2-Chloro-3-[2-ethyl-4-(phenylmethyl)-1-piperazinyl]pyrazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-dichloropyrazine (3.9 g, 27 mmol), 1-benzyl-3-ethylpiperazine (4.6 g, 22 5 mmol; from Step 1) and K2CO3 (6.2 g, 45 mmol) in DMF (10 mL) was stirred at 100° C. for 4 days The solvent from the filtered reaction mixture was evaporated off and the residue was purified by column chromatography on silica using heptane/EtOAc (90:10) as eluent to yield 5.0 g (71%) of the title compound as a light yellow oil. HRMS m/z calcd for C17H21ClN4 (M)+ 316 1455, found 3 16.1448

Provenance & Evidence