p-Toluenesulfonic acid → 1-{5-[2-(3,4-Bis-hydroxymethyl-phenyl)ethyl]-2-thienyl}-1-propanone

Participants

Reaction Steps

In a manner similar to that of Example 6(g), by reaction of 8.7 g (23 mmol) of (4-{2-[5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienyl]ethyl}-2-hydroxymethylphenyl)methanol with a solution of para-toluenesulphonic acid in an acetone/water mixture, the desired product is obtained in the form of a white powder (m=5.41 g; Y=71%).

Provenance & Evidence