Bromine → HCID 11565801, compound

HRID 493377Notes

Reaction equation

HRID 493377 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Br:18]Br>C(O)C>[Br:18][CH2:14][C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:16]=[CH:17][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1)=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 27590561-[4-(4-fluorophenoxy)phenyl]ethanone

Product 1

HCID 11565801HCID 11565801, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-[4-(4-fluorophenoxy)phenyl]ethanone (17.7 g, 0.077 mol) in 220 ml of ethanol is cooled down to approximately 0° C. Bromine (4.8 ml, 0.096 mol) is added dropwise with a syringe. The temperature is allowed to return to ambient temperature, followed by stirring for 2 hours. After evaporation of the solvent then stirring for 10 hours in isopentane, the residue is filtered on frit and dried under a vacuum chamber bell jar. A beige-coloured powder is obtained.

Workup

  1. customto return to ambient temperature
  2. customAfter evaporation of the solvent
  3. stirringthen stirring for 10 hours in isopentane
  4. filtrationthe residue is filtered on frit
  5. customdried under a vacuum chamber bell jar
  6. customA beige-coloured powder is obtained

Sources & evidence

ORD record
ord-1005f21daa09443ab75616966a8c7631
Source dataset
uspto-grants-2009_05
Patent number
US07534805B2

Reaction notes

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