反应详情

A solution of 1-[4-(4-fluorophenoxy)phenyl]ethanone (17.7 g, 0.077 mol) in 220 ml of ethanol is cooled down to approximately 0° C. Bromine (4.8 ml, 0.096 mol) is added dropwise with a syringe. The temperature is allowed to return to ambient temperature, followed by stirring for 2 hours. After evaporation of the solvent then stirring for 10 hours in isopentane, the residue is filtered on frit and dried under a vacuum chamber bell jar. A beige-coloured powder is obtained.

1. customto return to ambient temperature
2. customAfter evaporation of the solvent
3. stirringthen stirring for 10 hours in isopentane
4. filtrationthe residue is filtered on frit
5. customdried under a vacuum chamber bell jar
6. customA beige-coloured powder is obtained