HCID 178514486, compound → HCID 178507417, compound

HRID 493380Notes

Reaction equation

HRID 493380 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[NH:13][CH:14]=2)=[CH:6][CH:5]=1)=[N+]=[N-]>C(OCC)C.[Pd]>[O:16]([CH2:15][C:12]1[NH:13][CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 178514486HCID 178514486, compound

Product 1

HCID 178507417HCID 178507417, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3283Diethyl EtherSolvent2×

Procedure

In a 100 ml reactor, 549 mg of 4-(4-azidophenyl)-2-(phenoxymethyl)-1H-imidazole (0.00188 mol) are hydrogenated over 18 hours under a hydrogen pressure of 2.5 bars with a catalytic quantity of palladium adsorbed on carbon (10% by mass). After filtration on a millipore filter then rinsing with ethanol and concentration to dryness, the residue thus obtained is treated with diethyl ether. After stirring in diethyl ether, the solid is filtered. After drying a white-coloured powder is obtained.

Workup

  1. filtrationAfter filtration on a millipore
  2. filtrationfilter
  3. washthen rinsing with ethanol and concentration to dryness
  4. customthe residue thus obtained
  5. filtrationthe solid is filtered
  6. customAfter drying a white-coloured powder
  7. customis obtained

Sources & evidence

ORD record
ord-cad3d6942cfd490aaafe0b4a151ebf27
Source dataset
uspto-grants-2009_05
Patent number
US07534805B2

Reaction notes

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