HCID 1506501, compound → HCID 86012624, compound

HRID 493383Notes

Reaction equation

HRID 493383 reaction equation
[C:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br-:20].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>CO>[Br:20][CH2:2][C:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 1506501HCID 1506501, compoundHCID 21124087Pyridiniumtribromide

Product 1

HCID 86012624HCID 86012624, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

4-acetyl-N-(4-fluorophenyl)benzamide (1.5 g, 0.00583 mol) is dissolved in 100 ml of methanol. Pyridinium tribromide resin is added (4 g of resin to 2 mmol of Br3 per gram, 0.0081 mol) followed by heating for 4 hours at 40° C. The reaction medium is filtered on frit, rinsed with methanol and evaporated to dryness. A pale yellow-coloured powder is obtained.

Workup

  1. filtrationThe reaction medium is filtered on frit
  2. washrinsed with methanol
  3. customevaporated to dryness
  4. customA pale yellow-coloured powder is obtained

Sources & evidence

ORD record
ord-750c88d30d844e0cb8063d98cd1e9ea6
Source dataset
uspto-grants-2009_05
Patent number
US07534805B2

Reaction notes

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