HCID 178420401, compound → HCID 178516270, compound

Participants

Reaction Steps

In a 100 ml reactor, 138 mg of 4-{4-[4-(benzyloxy)phenoxy]phenyl}-2-(phenoxymethyl)-1H-imidazole (0.0003 mol) in 10 ml of ethanol with a catalytic quantity of palladium adsorbed on carbon (10% by mass), are hydrogenated for 24 hours under a hydrogen pressure of 4 bars. The reaction medium is filtered on a millipore filter then rinsed with ethanol and evaporated to dryness. The residue is triturated with diethyl ether and the mixture is stirred in diethyl ether and the solid is filtered. The product obtained is adsorbed on silica then purified by chromatography on a Biotage-type silica column (eluent: ethyl acetate-heptane: 2-8 to 5-5). After washing with diethyl ether, a white-coloured powder is obtained.

Provenance & Evidence