2-Bromo-2-methylpropionyl bromide → HCID 18386553, compound

Participants

Reaction Steps

4.30 (32.20 mol) of AlCl3 were added in portion under stirring to a solution of 2.5 g (7.32 mmol) of 2-methyl-2-morpholin yl-1-(4-phenylsulphanyl-phenyl)-propan-1-one and 1.81 g (7.69 mmol) of α-bromoisobutyrylbromide (97.5% w/w) in 50 ml of dichloromethane, between 0 e 5° C. At the end of the addition the temperature was brought to 25° C. then, after 2.5 h, the reaction was quenched in 200 ml of iced water. The organic phase was separated and washed with water and 5% NaOH then dried with sodium sulphate, filtered and evaporated obtaining 3.59 g of product as a reddish oil.

Provenance & Evidence