Water → HCID 83806163, compound

Participants

Reaction Steps

4-(4-fluorophenyl)-1-methyl-4-piperidinecarboxylic acid hydrochloride (273 mg) was dissolved in dry toluene (10 mL) and, under a Nitrogen athmosphere and at r.t., TEA (0.33 mL) and diphenylphosphoryl azide (0.34 mL) were added. The mixture was refluxed for 4 h. Then water and AcOEt were added; the organic phase was separated and washed with brine, dried and evaporated under vacuum to give a crude which was purified by flash chromatography (elution with DCM:MeOH 9:1) to afford the title compound (47 mg) as white foam.

Provenance & Evidence