Hydrochloric Acid → HCID 11236744, compound

Participants

Reaction Steps

A mixture of methyl({4′-[({[1-phenyl-5-propyl-1H-pyrazol-4-yl]carbonyl}amino)methyl][1,1′-biphenyl]-4-yl}oxy)acetate (250 mg, 0.517 mmol), prepared in the previous step, and 1 N NaOH (620 μL, 0.620 mmol) in 40 mL of THF and 20 mL of water was stirred at room temperature for 19 h (overnight). The reaction was acidified by the addition of 620 μL of 1 N HCl and then concentrated under reduced pressure to remove the THF. The solid that formed was collected by filtration and dried under reduced pressure to give the title compound (214 mg, 87%) as a white solid, mp 190-192° C. Elemental Analysis for C28H27N3O4+0.43 H2O. Calc'd: C, 70.46; H, 5.88; N, 8.80. Found: C, 70.37; H, 5.98; N, 8.44

Provenance & Evidence