Potassium Carbonate → HCID 131727449, compound

Participants

Reaction Steps

A mixture of N-[(3′-bromo-4′-hydroxy-1,1′-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide (1.01 g, 2.04 mmol), prepared in step 7 of Example 6, methyl bromoacetate (213 μL, 2.25 mmol) and potassium carbonate (1.41 g, 10.2 mmol) in 20 ml of DMF was stirred under nitrogen at room temperature for 23 h (overnight). The reaction was partitioned between ethyl acetate and water. The organic layer was separated, extracted multiple times with water, dried (MgSO4) and the solvent removed under reduced pressure to give methyl[(3-bromo-4′-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)amino]methyl}-1,1′-biphenyl-4-yl)oxy]acetate (1.07 g, 93%) as a yellow oil, MS (ESI) m/z 564 [M+H]+. Elemental Analysis for C30H30BrNO5. Calc'd: C, 63.83; H, 5.36; N, 2.48. Found: C, 63.42; H, 5.40; N, 2.39.

Provenance & Evidence