Water → HCID 11239127, compound

Participants

Reaction Steps

1 N NaOH (2.28 mL, 2.28 mmol) was added under nitrogen to a solution of methyl2-[(3-bromo-4′-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)amino]methyl}-1,1′-biphenyl-4-yl)oxy]-3-phenylpropanoate (995 mg, 1.52 mmol), prepared in the previous step, in 100 mL of methanol plus 10 mL of water. After the addition the reaction was refluxed for 5 h. The reaction was filtered, acidified with 2.5 mL of 1 N HCl and concentrated under reduced pressure to remove the methanol. The solid that was present was collected by filtration and dried under reduced pressure to give the title compound (900 mg, 92%) as a white solid, mp 79-86° C. Elemental Analysis for C36H34BrNO5Calc'd: C, 67.50; H, 5.35; N, 2.19. Found: C, 6 7.16; H, 5.42; N, 2.09

Provenance & Evidence