Dimethylformamide → 2-(2-Ethyl-[1,3]dioxolan-2-yl)thiophene-4-carbaldehyde

Participants

Reaction Steps

In a manner similar to that of Example 9(g), by reaction of 12 g (45.6 mmol) of 2-(4-bromo-2-thienyl)-2-ethyl-[1,3]dioxolane with 20 mL (50 mmol) of 2.5 M butyllithium and 3.9 mL (50 mmol) of dimethylformamide, the desired product is obtained in the form of a yellow oil (m=4.6 g, Y=48%).

Provenance & Evidence