反应详情

A mixture of (4′-nitro-biphenyl-4-yloxy)-acetic acid methyl ester (2.26 g, 7.86 mmol), prepared in the previous step, and 10% palladium on carbon in methanol was hydrogenated under a hydrogen atmosphere at room temperature. The reaction was filtered and the filtrate concentrated under reduced pressure. Purification of the residue on silica gel using 20% ethyl acetate hexanes as the eluent gave (4′-amino-biphenyl-4-yloxy)-acetic acid methyl ester (700 mg. 31%).

1. customwas hydrogenated under a hydrogen atmosphere at room temperature
2. filtrationThe reaction was filtered
3. concentrationthe filtrate concentrated under reduced pressure
4. customPurification of the residue on silica gel using 20% ethyl acetate hexanes as the eluent