p-Toluenesulfonic acid → 1-{4-[2-(3,4-Bis-hydroxymethyl-phenyl)ethyl]-2-thienyl}-1-propanone

Participants

Reaction Steps

In a manner similar to that of Example 6(g), by reaction of 5.3 g (15 mmol) of (4-{2-[2-(2-ethyl-[1,3]dioxolan-2-yl)-4-thienyl]ethyl}-2-hydroxymethyl-phenyl)methanol with a solution of para-toluenesulphonic acid in an acetone/water mixture, the desired product is obtained in the form of a white powder (m=4 g; Y=86%).

Provenance & Evidence