Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 493532Generated: October 30, 2026

2-Fluorophenol → Methyl 5-chloro-2-[(2-fluorophenoxy)methyl]benzoate

https://huagongshe.com/reaction/493532

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-FluorophenolHCID 9707—
ReactantMethyl 2-(bromoethyl)-5-chlorobenzoateHCID 68983888—
ProductMethyl 5-chloro-2-[(2-fluorophenoxy)methyl]benzoateHCID 68862280—

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 1 from methyl 2-(bromoethyl)-5-chlorobenzoate and 2-fluorophenol: 1H-NMR (CDCl3)  8.02 (1H, d, J=2.4 Hz), 7.80-7.77 (1H, m), 7.57-7.53 (1H, m), 7.15-6.89 (4H, m), 5.52 (2H, s), 3.92 (3H, s).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07534914B2
Source datasetuspto-grants-2009_05
ORD IDord-dde226be132e4438aac2a87e802b4d1e
Source noteuspto-grants-2009_05