(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 68864776, compound

HRID 493563Notes

Reaction equation

HRID 493563 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][C:8]2[N:16]=[CH:15][C:14]([F:17])=[CH:13][C:9]=2[C:10]([OH:12])=O)=[CH:4][CH:3]=1.Cl.[NH2:21][C@H:22]([C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1)[CH3:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[C:9]([C:10]([NH:21][C@H:22]([C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=3)[CH3:23])=[O:12])=[CH:13][C:14]([F:17])=[CH:15][N:16]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 68862279HCID 68862279, compound

Product 1

HCID 68864776HCID 68864776, compound

Procedure

The title compound was prepared according to the procedure described in step 6 of Example 1 from 2-[(4-chlorophenoxy)methyl]-5-fluoronicotinic acid (step 5) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 5 of Example 1):

Sources & evidence

ORD record
ord-76f21452115c4b4f87c60ad6ee32700e
Source dataset
uspto-grants-2009_05
Patent number
US07534914B2

Reaction notes

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