(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 68863682, compound

HRID 493575Notes

Reaction equation

HRID 493575 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:21][C@H:22]([C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1)[CH3:23]>>[CH3:31][O:30][C:28](=[O:29])[C:27]1[CH:32]=[CH:33][C:24]([C@@H:22]([NH:21][C:7]([C:6]2[C:5]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[N:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)=[O:9])[CH3:23])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 68862411HCID 68862411, compound

Product 1

HCID 68863682HCID 68863682, compound

Procedure

The title compound was prepared according to the procedure described in step 6 of Example 1 from 5-chloro-2-[(4-fluorophenoxy)methyl]nicotinic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 5 of Example 1):

Sources & evidence

ORD record
ord-c8ad617f30bc4a859155e13e33e9445e
Source dataset
uspto-grants-2009_05
Patent number
US07534914B2

Reaction notes

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