HCID 20636303, compound → 1{5-[3,4-Bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-3-thienyl}-1-propanol

HRID 49359Notes

Reaction equation

HRID 49359 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:22]=[CH:23][C:24]=1[CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:29])[CH3:28])[O:13][CH2:14][C:15]1[S:19][CH:18]=[C:17]([CH:20]=[O:21])[CH:16]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH2:34]([Mg]Br)[CH3:35]>>[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:22]=[CH:23][C:24]=1[CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:28])[CH3:29])[O:13][CH2:14][C:15]1[S:19][CH:18]=[C:17]([CH:20]([OH:21])[CH2:34][CH3:35])[CH:16]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 20636303HCID 20636303, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 698246201{5-[3,4-Bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-3-thienyl}-1-propanol

Procedure

In a manner similar to that of Example 9(a), by reaction of 33 g (65 mmol) of 5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]thiophene-3-carbaldehyde with 44 mL (130 mmol) of ethylmagnesium bromide, the product is obtained in the form of a yellow oil (m=28.4 g; Y=88%).

Workup

  1. customthe product is obtained in the form of a yellow oil (m=28.4 g; Y=88%)

Sources & evidence

ORD record
ord-f73dd451cda54ecda12457504bb9f7d9
Source dataset
uspto-grants-2004_03
Patent number
US06706725B1

Reaction notes

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