Trifluoroacetic acid → Trifluoroacetic acid

HRID 493660노트

반응식

HRID 493660 반응식
C(OC([N:8]([C@@H:16]1[CH2:22][CH2:21][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=2[F:30])[CH2:19][N:18]([CH2:31][C:32]([OH:35])([CH3:34])[CH3:33])[C:17]1=[O:36])C(OC(C)(C)C)=O)=O)(C)(C)C.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>C(Cl)Cl>[NH2:8][C@@H:16]1[CH2:22][CH2:21][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=2[F:30])[CH2:19][N:18]([CH2:31][C:32]([OH:35])([CH3:33])[CH3:34])[C:17]1=[O:36].[C:39]([OH:41])([C:38]([F:43])([F:42])[F:37])=[O:40]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 21114341Di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

생성물 2

HCID 6422Trifluoroacetic acidHCID 60037871(3R,6S)-3-Amino-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)azepan-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of di-tert-butyl[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate (0.095 g, 0.185 mmol) in DCM (10 mL) was treated with trifluoroacetic acid (3 mL). After 1 h the reaction was concentrated to dryness to afford the title compound as a TFA salt. MS 313.2 (M+1).

후처리

  1. concentrationAfter 1 h the reaction was concentrated to dryness

출처 및 근거

ORD 기록
ord-08e504e3f9bc459a9172341b83296a8d
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534784B2

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