Ethanolamine → HCID 178482541, compound

Participants

Reaction Steps

1-(3-((6-Chloro-2-naphthyl)sulfonyl)propanoyl)-4-(((2Z)-3-methyl-2-(methylimino)-2,3-dihydro-1,3-thiazol-4-yl)methyl)piperazine-2-carboxylic acid dihydrochloride (0.4 g) obtained in Example 24 was dissolved in DMF (20 mL), and triethylamine (0.2 mL) was added thereto. With ice cooling, 2-ethanolamine (0.04 g), HOBt (0.12 g) and WSC (0.16 g) were added thereto, and the mixture was mixed at room temperature for 16 hours. The reaction solution was basified with an aqueous potassium carbonate solution, then extracted with chloroform, and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified with a basic silica gel column to give the title compound (0.21 g) as a white powder.

Provenance & Evidence