HCID 57681536, compound → HCID 23131095, compound

Participants

Reaction Steps

tert-Butyl ((2Z)-5-bromo-4-((4-(3-((6-chloro-2-naphthyl)sulfonyl)propanoyl)-1-piperazinyl)methyl)-3-methyl-1,3-thiazol-2(3H)-ylidene)carbamate (1.2 g) obtained in Example 30c) was dissolved in trifluoroacetic acid (10 mL), and the mixture was mixed at room temperature for 1 hour. The solvent was distilled off, and the residue was poured into an aqueous potassium carbonate solution. The mixture was extracted with a mixed solution of chloroform-methanol, and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified with a basic silica gel column to give the title compound (0.07 g) as a pale brown powder.

Provenance & Evidence