Tetrabutylammonium Fluoride → (4E,6E)-7-(4-{2-[3,4-bis-hydroxymethyl-phenyl]ethyl}-2-thienyl)-3-ethylnona-4,6-dien-3-ol

Participants

Reaction Steps

In a manner similar to that of Example 7(f), by reaction of 440 mg (0.68 mmol) of (4E,6E)-7-(4-{2-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenyl]ethyl}-2-thienyl)-3-ethylnona-4,6-dien-3-ol with 1.5 mL (1.5 mmol) of 1 M tetrabutylammonium fluoride solution, (4E,6E)-7-(4-{2-[3,4-bis-hydroxymethyl-phenyl]ethyl}-2-thienyl)-3-ethylnona-4,6-dien-3-ol is obtained in the form of a yellow oil (m=200 mg; Y=71%).

Provenance & Evidence