反应详情

To a solution of tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate (Wityak J., et al., J. Med. Chem., 40, p. 50 (1997): 27.6 g) in diethyl ether was added dibromobarbituric acid (17.0 g), and the mixture was mixed for 12 hours. The insolubles were filtered off, and the filtrate was diluted with diethyl ether, sequentially washed with a saturated aqueous sodium bicarbonate solution and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off to give the title compound (31.8 g) as a pale yellow viscous oily matter.

1. additionthe mixture was mixed for 12 hours
2. filtrationThe insolubles were filtered off
3. additionthe filtrate was diluted with diethyl ether
4. washsequentially washed with a saturated aqueous sodium bicarbonate solution and saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was distilled off