Dimethylbarbituric acid → HCID 23131006, compound

Participants

Reaction Steps

To a solution of allyl (2Z)-5-(1-(3-((6-chloro-2-naphthyl)sulfonyl)propanoyl)-4-piperidinyl)-3-methyl-1,3-thiazol-2(3H)-ylidenecarbamate (0.60 g) obtained in Example 57d) in THF, 1,3-dimethylbarbituric acid (0.25 g) and tetrakis(triphenylphosphine)palladium (0.06 g) were added thereto and mixed for 12 hours under argon atmosphere. The insolubles were filtered off, and the filtrate was concentrated. The residue was purified with a silica gel column to give the title compound (0.32 g) as a pale yellow solid.

Provenance & Evidence