Hydrogen Peroxide → HCID 178482533, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-((2Z,4E)-4-(cyanomethylene)-3-methyl-2-(methylimino)-1,3-thiazolidin-5-yl)piperidine-1-carboxylate (0.30 g) obtained in Example 74a) in DMSO (6.0 mL) were added potassium carbonate (0.1 g) and a 30% aqueous hydrogen peroxide solution (1 mL) at 0° C. and mixed for 30 minutes. The reaction solution was diluted with ethyl acetate, washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off, and the residue was crystallized from hexane to give the title compound (0.32 g) as a colorless solid.

Provenance & Evidence