Selenium Dioxide → 4-Methyl-3-oxo-3,4-dihydro-quinoxaline-2-carbaldehyde

Participants

Reaction Steps

A mixture of 1,3-dimethyl-1H-quinoxalin-2-one (1 g) and selenium dioxide (1.33 g, 2.1 eq) in dry dioxane (60 mL) was stirred at reflux under nitrogen for 30 min. After cooling, the dark-brown mixture was concentrated under reduced pressure and the residue was purified by FC (AcOEt) to give the title compound as a yellow solid.

Provenance & Evidence