2,2,2-Trifluoroethyl trifluoromethanesulfonate → [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-methanone

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from [6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-methanone (Example 6, step 4) and 2,2,2-trifluoroethyltrifluoromethanesulfonate. The desired product was obtained in a yield of 15% as white solid. MS (m/e): 580.1 (M+H, 100%).

Provenance & Evidence