2-Chloropyridine-4-boronic acid → [6-Bromo-1-(2-chloro-pyridin-4-yl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-methanone

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of example 5, the title compound was synthesized from [6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-methanone (Example 6, step 4) and 2-chloropyridine-4-boronic acid. The desired product was obtained in a yield of 7% as white solid. MS (m/e): 609.0 (M+H, 100%).

Provenance & Evidence