HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropionitrile → Rac-2-[2-(1,1-dioxo-1lambda6-thiomorpholine-4-carbonyl)-5-(1-isopropyl-piperidin-4-yloxy)-indol-1-yl]-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropionitrile | HCID 140538 | — |
| Reactant | (1,1-Dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone | HCID 16739577 | — |
| Product | Rac-2-[2-(1,1-dioxo-1lambda6-thiomorpholine-4-carbonyl)-5-(1-isopropyl-piperidin-4-yloxy)-indol-1-yl]-propionitrile | HCID 16739644 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from (1,1-dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (Example 2) and 2-bromopropionitrile. The desired product was obtained in a yield of 20% as a light yellow foam. MS (m/e): 473.6 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538101B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-3ce1b06df2804f8e9b47d963b468bf69 |
| Source note | uspto-grants-2009_05 |