(2-Bromoethoxy)-tert-butyldimethylsilane → [6-Bromo-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-methanone

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from [6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-methanone (Example 6, step 4) and (2-bromoethoxy)-tert-butyldimethylsilane. The desired product was obtained in a yield of 50% as colorless oil. MS (m/e): 656.4 (M+H, 50%).

Provenance & Evidence