1-Benzylpiperazine → HCID 18321042, compound

HRID 494020Notes

Reaction equation

HRID 494020 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]([N:21]1[CH2:26][CH2:25][C:24](=O)[CH2:23][CH2:22]1)([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:2]1([CH2:1][N:8]2[CH2:13][CH2:12][N:11]([CH:24]3[CH2:25][CH2:26][N:21]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:22][CH2:23]3)[CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 18321042HCID 18321042, compoundYield 60%

Procedure

In operating analogously to preparation XXVIII, starting with N-benzylpiperazine and N-Boc-4-piperidinone, the product sought after is obtained as a colourless oil (yield=60%).

Sources & evidence

ORD record
ord-8c852881eea1487991848eb5b0310c1a
Source dataset
uspto-grants-2009_05
Patent number
US07538111B2

Reaction notes

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