Phenylboronic Acid → HCID 86617218, compound

Participants

Reaction Steps

Proceeding as described in Example 6 above, but substituting tert-butyl 2-(4-((3-bromophenyl)(phenyl)methyl)piperazin-1-yl)acetate with 2-((R)-2-methyl-4-((R)-(4-bromophenyl)(phenyl)methyl)piperazin-1-yl)acetate and treating it with phenylboronic acid, 2-methylphenylboronic acid, 3-methylphenylboronic acid and 4-methylphenylboronic acid provided tert-butyl ((R)-2-methyl-4-((R)-(4-biphenyl)(phenyl)methyl)-piperazin-1-yl)acetate, tert-butyl ((R)-2-methyl-4-((R)-(4-(2-methylphenyl)phenyl)(phenyl)methyl)-piperazin-1-yl)acetate, tert butyl ((R)-2-methyl-4-((R)-(4-(3-methylphenyl)phenyl)-(phenyl)methyl)-piperazin-1-yl)acetate, and tert-butyl ((R)-2-methyl-4-((R)-(4-(4-methylphenyl)phenyl)-(phenyl)methyl)-piperazin-1-yl)acetate respectively, which were converted to [(R)-4-((R)-biphenyl-4-yl-phenyl-methyl)-2-methyl-piperazin-1-yl]-acetic acid; {(R)-2-methyl-4-[(R)-(2′-methyl-biphenyl-4-yl)-phenyl-methyl]-piperazin-1-yl}-acetic acid; {(R)-2-methyl-4-[(R)-(3′-methyl-biphenyl-4-yl)-phenyl-methyl]-piperazin-1-yl}-acetic acid; and {(R)-2-methyl-4-[(R)-(4′-methyl-biphenyl-4-yl)-phenyl-methyl]-piperazin-1-yl}-acetic acid, respectively, as described in Example 4 above.

Provenance & Evidence