Cesium carbonate → HCID 68865751, compound

Participants

Reaction Steps

A mixture of 10-(benzyloxy)-6,8-dimethyl-7,8-dihydropyrazino[1′,2′:1,5]-pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.12 g, 0.34 mmol), 4-fluorobenzyl bromide (63 μL, 0.34 mmol), and cesium carbonate (0.22 g, 0.68 mmol) in anhydrous DMF (1 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated under vacuum and the residue partitioned between ethyl acetate and aqueous citric acid. The organic extract was washed with brine, dried over MgSO4, filtered, and concentrated to provide the titled dione. The residue was subjected to column chromatography on silica gel eluted with a methanol-chloroform gradient to provide the titled product.

Provenance & Evidence