Boron tribromide → HCID 54697525, compound

Participants

Reaction Steps

To a solution of 4-amino-2-(4-fluorobenzyl)-10-(benzyloxy)-8-methyl-7,8-dihydropyrazino[1′,2′:1,5]-pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.11 g, 0.25 mmol) in dichloromethane (10 mL) at 0° C., a solution of boron tribromide in dichloromethane (0.7 mL, 1M) was added. The resultant solution was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and the residue subjected to purification on reverse phase HPLC. Collection and lyophilization of appropriate fractions provided the titled compound.

Provenance & Evidence