Potassium Carbonate → HCID 68864518, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10-(benzyloxy)-2-(3-chloro-4-fluorobenzyl)-8-methyl-4-bromo-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.15 g, 0.28 mmol), copper (I) iodide (27 mg, 0.14 mmol), potassium carbonate (76 mg, 0.55 mmol), and 2-hydroxypyridine (52 mg, 0.55 mmol) in N-methyl-2-pyrrolidinone (2.7 mL) was stirred in an oil bath at 140° C. for 3 hours. The resultant mixture was filtered and concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with a 1-5% methanol in chloroform gradient. Collection and concentration of appropriate fractions provided the title compound. ES MS M+1=560

Provenance & Evidence