Acetic Acid → HCID 68865233, compound

Participants

Reaction Steps

A solution of the above hydrazinecarboxamide (0.20 g, 0.34 mmol) and glacial acetic acid (0.1 mL) in absolute ethanol (5 mL) was heated in a sealed tube in an oil bath at 100° C. overnight. The reaction mixture was concentrated under vacuum. The residue was partitioned between chloroform and aqueous sodium bicarbonate. The organic extract was washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum to provide the corresponding cyclized trazinyl intermediate. ES MS M+1=564

Provenance & Evidence