2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 69039398, compound

HRID 494181Notes

Reaction equation

HRID 494181 reaction equation
CN([CH:4]([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)=O)C.[NH2:15]/[C:16](/[CH3:23])=[CH:17]\[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[F:13][C:9]1[CH:8]=[C:7]([C:5]2[CH:4]=[CH:14][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:16]([CH3:23])[N:15]=2)[CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 69043294HCID 69043294, compound

Product 1

HCID 69039398HCID 69039398, compound

Procedure

The title compound was prepared from dimethylamino-(3-fluorophenyl)propan-1-one and ethyl 3-aminocrotonate using the general procedure outlined in D18. 1H NMR (250 MHz, CDCl3) δ (ppm): 8.27 (d, 1H), 7.83 (m, 2H), 7.61 (d, 1H), 7.44 (m, 1H), 7.13 (m, 1H), 4.41 (q, 2H), 2.91 (s, 3H), 1.42 (t, 3H).

Sources & evidence

ORD record
ord-631b63b96a3340108b2390d777f2f4dc
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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