N,N-Dimethylaminoethyl chloride hydrochloride → HCID 69039894, compound

HRID 494196Notes

Reaction equation

HRID 494196 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[CH:9]=[CH:8][C:7]=1[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1.Cl.CN(C)CCCl>>[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[CH:9]=[CH:8][C:7]=1[C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 69037624HCID 69037624, compound

Product 1

HCID 69039894HCID 69039894, compound

Procedure

Using the procedure outlined in Description 77, the title compound was prepared from methyl 2-(2-dimethylaminoethoxy)-4′-fluoro-1,1′-biphenyl-4-carboxylate (D78) (200 mg, 0.61 mmol)) and 2-(dimethylamino)ethylchloride hydrochloride (114 mg, 0.79 mmol) as a solid (122 mg). MS(ES): MH+ 304, M-H+ 302.

Sources & evidence

ORD record
ord-c99e76540701414cb5c37cc03760df36
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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