2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 69042184, compound

HRID 494209Notes

Reaction equation

HRID 494209 reaction equation
CN([CH:4]([CH3:15])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([F:14])[CH:8]=1)=O)C.[NH2:16]/[C:17](/[CH3:24])=[CH:18]\[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[F:14][C:9]1[CH:8]=[C:7]([C:5]2[CH:4]=[CH:15][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:17]([CH3:24])[N:16]=2)[CH:12]=[CH:11][C:10]=1[F:13]

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 43794773HCID 43794773, compound

Product 1

HCID 69042184HCID 69042184, compound

Procedure

The title compound was prepared from dimethylamino-(3,4-difluorophenyl)-propan-1-one and ethyl 3-aminocrotonate using the general procedure outlined in D18. 1H NMR (250 MHz, CDCl3) δ (ppm): 8.26 (d, 1H), 7.96 (ddd, 1H), 7.79 (m, 1H), 7.57 (d, 1H), 7.20-7.31 (m, 1H), 4.40 (q, 2H), 2.90 (s, 3H), 1.42 (t, 3H).

Sources & evidence

ORD record
ord-cd40e072d7f1427f80feda8f0be61619
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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