(1,1'-Biphenyl)-4-carboxylic acid → HCID 57682671, compound

HRID 494222Notes

Reaction equation

HRID 494222 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][N:9]2[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[C:20]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:23]([C:26](O)=[O:27])=[CH:22][CH:21]=1>>[N:14]1([CH2:13][CH2:12][N:9]2[C:10]3[C:5](=[CH:4][CH:3]=[C:2]([NH:1][C:26]([C:23]4[CH:24]=[CH:25][C:20]([C:29]5[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=5)=[CH:21][CH:22]=4)=[O:27])[CH:11]=3)[CH2:6][CH2:7][CH2:8]2)[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 39361577HCID 39361577, compound

Product 1

HCID 57682671HCID 57682671, compound

Procedure

Using the procedure outlined in Example 35, the title compound was prepared from 7-amino-1-(2-morpholin-4-ylethyl)-1,2,3,4-tetrahydroquinoline (D17) (0.1 mmol) and 4-biphenylcarboxylic acid (24 mg, 0.12 mmol) as a red gum. 1H NMR (250 MHz, CDCl3) δ (ppm): 7.94 (d, 2H), 7.86 (br, 1H), 7.69 (d, 2H), 7.62 (d, 2H), 7.50 (t, 2H), 7.39 (t, 1H), 7.13 (d, 1H), 6.91 (d, 1H), 6.78 (dd, 1H), 3.75 (m, 4H), 3.46 (m, 2H), 3.33 (m, 2H), 2.80-2.40 (m, 8H), 1.92 (qn, 2H).

Sources & evidence

ORD record
ord-e284866011f5448a990c68cf9b59c005
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

Loading…