(1,1'-Biphenyl)-4-carboxylic acid → HCID 44415432, compound

HRID 494228Notes

Reaction equation

HRID 494228 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1.[C:13]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:17][C:16]([C:19](O)=[O:20])=[CH:15][CH:14]=1>>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:19]([C:16]3[CH:17]=[CH:18][C:13]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)=[CH:14][CH:15]=3)=[O:20])=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 1847561891817-59-3

Product 1

HCID 44415432HCID 44415432, compound

Procedure

Using the procedure outlined in Example 25, the title compound was prepared from N-methyl-6-amino-1,2,3,4-tetrahydroquinoline (International Patent Application, Publication number WO 94/14801) (75 mg, 0.46 mmol) and 4-biphenylcarboxylic acid (140 mg, 0.71 mmol) as a yellow gum. 1H NMR (250 MHz, CDCl3) δ (ppm): 8.03 (d, 2H), 7.6-7.8 (m, 5H), 7.4-7.55 (m, 3H), 7.2-7.35 (m, 2H), 6.59 (d, 1H), 3.21 (m, 2H), 2.89 (s, 3H), 2.79 (m, 2H), 1.99 (m, 2H).

Sources & evidence

ORD record
ord-93a148eef6e344daa80791ba6ddb462a
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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