HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-6-(3-fluorophenyl)-nicotinic acid → 6-(3-Fluorophenyl)-2-methyl-N-(1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-6-(3-fluorophenyl)-nicotinic acid | HCID 69039601 | — |
| Reactant | 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone | HCID 82048422 | — |
| Product | 6-(3-Fluorophenyl)-2-methyl-N-(1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide | HCID 57682683 | — |
Reaction Steps
Using the procedure outlined in Example 38, the title compound was prepared from 7-amino-1-trifluoroacetyl-1,2,3,4-tetrahydroquinoline (D5) (48 mg, 0.20 mmol) and 2-methyl-6-(3-fluorophenyl)-nicotinic acid (D25) (50 mg, 0.22 mmol) as an off-white solid. MS(ES): MH+ 362, M-H+ 360.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538121B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-7f1f1831da97479b99f231ed0f84c38b |
| Source note | uspto-grants-2009_05 |