2-Methyl-6-(2,3-difluorophenyl)-nicotinic acid → HCID 57682684, compound

HRID 494231Notes

Reaction equation

HRID 494231 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][N:9]2C(=O)C(F)(F)F)=[CH:4][CH:3]=1.[CH3:18][C:19]1[N:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=2[F:35])[CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22]>>[F:35][C:29]1[C:30]([F:34])=[CH:31][CH:32]=[CH:33][C:28]=1[C:26]1[CH:25]=[CH:24][C:20]([C:21]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][CH2:8][NH:9]3)=[CH:4][CH:3]=2)=[O:22])=[C:19]([CH3:18])[N:27]=1

Participants

3

Reactant 2

HCID 690395472-Methyl-6-(2,3-difluorophenyl)-nicotinic acidHCID 820484221-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone

Product 1

HCID 57682684HCID 57682684, compound

Procedure

Using the procedure outlined in Example 38, the title compound was prepared from 7-amino-1-trifluoroacetyl-1,2,3,4-tetrahydroquinoline (D5) (48 mg, 0.20 mmol) and 2-methyl-6-(2,3-difluorophenyl)-nicotinic acid (D26) (54 mg, 0.22 mmol) as an off-white solid. MS(ES): MH+ 380, M-H+ 378.

Sources & evidence

ORD record
ord-48dbf8d169774584bf8f1d8b244c159d
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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