7-Aminoquinoline → 3-Methoxy-N-quinolin-7-yl-1,1'biphenyl-4-carboxamide

HRID 494244Notes

Reaction equation

HRID 494244 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][C:19]=1[C:20](O)=[O:21]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][C:19]=1[C:20]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:21]

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 186874072-Methoxy-4-phenylbenzoic acid

Product 1

HCID 576826863-Methoxy-N-quinolin-7-yl-1,1'biphenyl-4-carboxamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (26 mg, 0.18 mmol) and 3-methoxy-1,1′-biphenyl-4-carboxylic acid (D59) (50 mg, 0.22 mmol) as an off-white solid. MS (ES): MH+ 355.

Sources & evidence

ORD record
ord-ab9e945985684653980d7f86cce33d32
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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