7-Aminoquinoline → 2-Methyl-N-quinolin-7-yl-1,1'biphenyl-4-carboxamide

HRID 494245Notes

Reaction equation

HRID 494245 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([C:19](O)=[O:20])[CH:16]=[CH:15][C:14]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH3:12][C:13]1[CH:18]=[C:17]([C:19]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[O:20])[CH:16]=[CH:15][C:14]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 215218102-Methyl-[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 576827262-Methyl-N-quinolin-7-yl-1,1'biphenyl-4-carboxamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (30 mg, 0.21 mmol) and 2-methyl-1,1′-biphenyl-4-carboxylic acid (D60) (53 mg, 0.25 mmol) as a white solid. MS(ES): MH+ 339

Sources & evidence

ORD record
ord-04ea3e4682b14397b1955f56b16ae808
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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