7-Aminoquinoline → HCID 69038950, compound

HRID 494246Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([CH3:32])[C:21]=1[C:22]1[CH:30]=[CH:29][C:25]2[O:26][CH2:27][O:28][C:24]=2[C:23]=1[CH3:31])[C:16](O)=[O:17]>>[CH3:32][C:20]1[CH:19]=[C:15]([CH:14]=[C:13]([CH3:12])[C:21]=1[C:22]1[CH:30]=[CH:29][C:25]2[O:26][CH2:27][O:28][C:24]=2[C:23]=1[CH3:31])[C:16]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:17]

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 69037925HCID 69037925, compound

Product 1

HCID 69038950HCID 69038950, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (17 mg, 0.12 mmol) and 3,5-dimethyl-4-(4-methyl-benzo[1,3]-dioxol-5-yl)-benzoic acid (D62) (41 mg, 0.15 mmol) as a yellow oil. MS(ES): MH+ 411, M-H+ 409.

Sources & evidence

ORD record: ord-1b183e3ac5b34c8bb3135256bd549cd7
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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