(1,1'-Biphenyl)-4-carboxylic acid → N-(2-Methylquinolin-7-yl)-1,1'-biphenyl-4-carboxamide

HRID 494247Notes

Reaction equation

HRID 494247 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1.[C:13]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:17][C:16]([C:19](O)=[O:20])=[CH:15][CH:14]=1>>[CH3:12][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:19]([C:16]3[CH:17]=[CH:18][C:13]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)=[CH:14][CH:15]=3)=[O:20])=[CH:3][CH:4]=2)[N:9]=1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 4596552-Methylquinolin-7-amine

Product 1

HCID 44415671N-(2-Methylquinolin-7-yl)-1,1'-biphenyl-4-carboxamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-2-methylquinoline (D66) (80 mg, 0.51 mmol) and 4-biphenylcarboxylic acid (149 mg, 0.75 mmol) as an off-white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.07 (m, 3H), 8.01 (m, 3H), 7.81 (d, 1H), 7.75 (d, 2H), 7.66 (d, 2H), 7.50 (t, 2H), 7.42 (t, 1H), 7.24 (d, 1H), 2.75 (s, 3H).

Sources & evidence

ORD record
ord-7abb67ffbd26420aad33f0fbaaa997aa
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

Loading…