2-Methylquinolin-7-amine → N-(2-Methylquinolin-7-yl)-4-(2-pyridyl)benzamide

HRID 494250Notes

Reaction equation

HRID 494250 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1>>[CH3:12][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][C:19]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=4)=[CH:20][CH:21]=3)=[CH:3][CH:4]=2)[N:9]=1

Participants

3

Reactant 2

HCID 4596552-Methylquinolin-7-amineHCID 8216924-(2-Pyridyl)Benzoic Acid

Product 1

HCID 57682688N-(2-Methylquinolin-7-yl)-4-(2-pyridyl)benzamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-2-methylquinoline (D66) (33 mg, 0.21 mmol) and 4-(2-pyridyl)benzoic acid (D67) (50 mg, 0.25 mmol) as a white solid. MS (ES): MH+ 340, M-H+ 338.

Sources & evidence

ORD record
ord-1d88eba274bc418796a9711c16075f70
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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